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08.01.2021 | Original Communication

Head tremor and pain in cervical dystonia

verfasst von: Jeanne P. Vu, Ha Yeon Lee, Qiyu Chen, Elizabeth Cisneros, Richard L. Barbano, Christopher G. Goetz, Joseph Jankovic, Hyder A. Jinnah, Joel S. Perlmutter, Brian D. Berman, Mark I. Appelbaum, Glenn T. Stebbins, Cynthia L. Comella, David A. Peterson

Erschienen in: Journal of Neurology | Ausgabe 5/2021

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Abstract

Background

Although head tremor (HT) and pain are prevalent in cervical dystonia (CD), their joint relationship to phenotypic features of focal dystonia remains unclear.

Objectives

We examined how severity of HT and pain are associated with age of CD onset and duration, and whether HT subtypes (“jerky” or “regular”) exhibit distinct relationships between severity of HT and pain.

Methods

The severity of HT and pain were assessed with the Toronto Western Spasmodic Torticollis Rating Scale in retrospective review of 188 CD patients recruited through the Dystonia Coalition.

Results

HT severity was associated with longer CD duration (p < 0.0005), whereas pain severity was associated with younger age at onset (p = 0.043). HT severity and pain severity were not correlated for jerky HT (p = 0.996), but positively correlated for regular HT (p = 0.01).

Conclusions

The distinct associations of HT and pain with age at onset, disease duration, and HT subtype further characterize the heterogeneity of CD’s clinical presentation and suggest similarly heterogeneous underlying mechanisms.

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Titel: Head tremor and pain in cervical dystonia
verfasst von: Jeanne P. Vu
Ha Yeon Lee
Qiyu Chen
Elizabeth Cisneros
Richard L. Barbano
Christopher G. Goetz
Joseph Jankovic
Hyder A. Jinnah
Joel S. Perlmutter
Brian D. Berman
Mark I. Appelbaum
Glenn T. Stebbins
Cynthia L. Comella
David A. Peterson
Publikationsdatum: 08.01.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Neurology / Ausgabe 5/2021
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-020-10378-5

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