In the 1890s, all patients diagnosed with breast cancer received the same aggressive surgical therapy. Since that time, breast cancer therapy has evolved to include de-escalation of surgical therapy and personalization of medical treatment.
verfasst von:
Nora C. Elson, Karen Wernke, Lauren M. Yoder, Angela N. Fellner, Kathleen M. Raque, Anne M. Kuritzky, Barbara A. Wexelman
Clinical management of metastatic breast cancer (MBC) in older patients is complex [ 1 , 2 ]. An analysis of the SEER database revealed that over a quarter (27.1%) of patients with MBC were older than 69 years of age [ 3 ]. In order to deliver safe …
verfasst von:
Swarali Y. Atre, Pamela R. Soulos, Nicole M. Kuderer, Cary P. Gross, Laura V. M. Baum, Michaela A. Dinan, Maryam B. Lustberg
Estrogen receptor-positive (ER +)/HER2-negative (HER2-) breast cancers measuring ≤ 2 cm typically exhibit a favorable prognosis due to their distinct molecular features and behavior, with minimal rates of recurrence and distant metastasis within 5 …
verfasst von:
María José Roca Navarro, Jose Mª Oliver Goldaracena, Diego Garrido Alonso, Ylenia Navarro Monforte, Teresa Díaz de Bustamante Durbán, Mª Vicenta Córdoba Chicote, Fernando García Martínez, Covadonga Martí Álvarez, Laura Yébenes Gregorio, Jose Luis Montes Botella, Carmen Martín Hervás, José Ignacio Sánchez Méndez
Patients with a genetic predisposition to breast cancer (BC) represent a minor but clinically meaningful subgroup of the disease. This predisposition accounts for 5–15% of the detected malignancies. It is mainly due to germline likely pathogenic …
verfasst von:
Nerina C. van der Merwe, Ines Buccimazza, Bianca Rossouw, Monica Araujo, Kholiwe S. Ntaita, Mardelle Schoeman, Karin Vorster, Kgabo Napo, Maritha J. Kotze, Jaco Oosthuizen
Despite advancements in the treatment of breast cancer, a patient’s ability to receive and complete National Comprehensive Care Network guideline-concordant breast cancer treatment is not guaranteed and is affected by a multitude of structural and …
verfasst von:
Maya Lubarsky, Alexandra E Hernandez, Brianna L Collie, Ashly C Westrick, Cheyenne Thompson, Susan B Kesmodel, Neha Goel
Due to the establishment of screening mammography for breast cancer detection, the number of non-palpable lesions has increased [ 1 ]. In those cases, breast conserving surgery is the gold standard, being wire-guided localization the most spread …
verfasst von:
Ángela Santana Valenciano, Sonia Rivas Fidalgo, Sara Corral Moreno, Verónica Gamero Medina, Carmen Martín Blanco, César Barsen Pérez Izquierdo, Antonio Mena Mateos, Jacobo Cabañas Montero, José María Fernández Cebrián
With improvements in breast imaging, the role of clinical breast exam (CBE) in screening average risk women is increasingly being questioned; with a recent report suggesting a very low yield in women undergoing regular mammography screening [ 1 ].
verfasst von:
Tehillah S. Menes, Douglas Zippel, Miri Sklair-Levy, Eitan Friedman, Rinat Bernstein-Molho, Renata Faermann, Dana Madorsky Feldman
Breast Cancer is the most common cancer globally and the fifth leading cause of cancer deaths [ 1 ]. In Norway, 4,247 new cases were reported in 2022 [ 2 ]. A panel of immunohistochemistry (IHC) biomarkers can classify breast cancer into four …
verfasst von:
Emma Rewcastle, Ivar Skaland, Einar Gudlaugsson, Silja Kavlie Fykse, Jan P. A. Baak, Emiel A. M. Janssen
Breast cancer is classified into subtypes based on the expression of hormone receptors and amplification of the human epidermal growth factor receptor 2 (HER2) gene. The treatment strategy is determined based on the subtype, and prognosis and …
In 2020, breast cancer emerged as the most prevalent type of cancer worldwide with approximately 2.3 million new cases and a staggering number of over 680,000 deaths [ 1 ]. The primary approaches for battling breast cancer typically involve …
Genitourinary Syndrome of Menopause (GSM) or vulvovaginal atrophy is reported in up to 75% of women after breast cancer (BC) [ 1 ]. Symptoms are more prevalent in women with BC compared to peers without [ 2 , 3 ]. Chemotherapy, treatment-induced …
verfasst von:
Antonia Pearson, Jill Chen, Haryana M. Dhillon, Belinda E. Kiely
Breast cancer is the most common malignancy in women in the United States and is the second-leading cause of cancer-related mortality [ 1 , 2 ]. The majority of breast cancer-related mortality is secondary to progression of metastatic disease.
verfasst von:
Lara Schwieger, Lauren M. Postlewait, Yi Liu, Stephanie Jou, Sha Yi, Limin Peng, Xiaoxian Li
Based on the worldwide cancer data released by CA Cancer J Clin 2021[ 1 ], breast cancer is the most prevalent malignant tumor worldwide at the moment. According to the data, breast cancer accounts for 15.5 percent of cancer mortality in women …
verfasst von:
Yuyang Zhang, Huali Wang, Huahui Zhao, Xueming He, Ya Wang, Hongjiang Wang
Triple-negative breast cancer (TNBC) is a heterogeneous and aggressive subgroup that accounts for approximately 10–20% of breast cancer diagnoses [ 1 ]. Administration of neoadjuvant chemotherapy (NAC) has demonstrated a survival benefit for those …
verfasst von:
Olivia White, Susan Dent, Kelly Westbrook, Hui-Jie Lee, Chengxin Yang, Heather N. Moore
Human epidermal growth factor receptor 2–positive (HER2 +) breast cancer is an aggressive phenotype that has a poor prognosis [ 1 ]. Current treatment guidelines for this type of breast cancer recommend use of multidrug chemotherapy (i.e., a …
Breast cancer (BC) is the most frequent cancer among women, with 55,000 new cases diagnosed annually in the UK and 2.2 million worldwide [ 1 ]. Because sentinel lymph nodes (SLNs) are the first nodes to be involved when BC metastasizes [ 2 ], it is …
verfasst von:
Surekha Barkur, Radu A. Boitor, Raluca Mihai, Navarasi S. Raja Gopal, Samuel Leeney, Alexey A. Koloydenko, Hazem Khout, Emad Rakha, Ioan Notingher
The 2024 cancer statistics estimated 313,510 new cases of invasive breast cancer and 42,780 related deaths in the United States (US) [ 1 ]. The survival outcomes of breast cancer have undergone a paradigm shift in recent decades, with a reported …
verfasst von:
Ashish Gupta, Arya Mariam Roy, Kush Gupta, Kristopher Attwood, Asha Gandhi, Stephen Edge, Kazuaki Takabe, Elizabeth Repasky, Song Yao, Shipra Gandhi
Ductal carcinoma in situ (DCIS) of the breast represents a heterogeneous group of precancerous lesions. The incidence of DCIS has dramatically increased due to screening mammography; however, it varies between countries. In Sweden, DCIS comprises …
verfasst von:
Carina Strell, Daniel Robert Smith, Antonis Valachis, Hellén Woldeyesus, Charlotta Wadsten, Patrick Micke, Irma Fredriksson, Aglaia Schiza
Vasomotor symptoms (VMS), including hot flashes and nocturnal sweats, are common treatment-related symptoms among individuals with breast cancer [ 1 , 2 ]. These symptoms are associated with reduced quality of life [ 3 , 4 ] and treatment …
verfasst von:
Katherine Marie Cole, Sharon McGee, Mark Clemons, Michelle Liu, Fiona MacDonald, Lisa Vandermeer, Terry L. Ng, Gregory Pond, Khaled El Emam
It is estimated that breast cancer accounted for 13.3% of all new cancer cases diagnosed in EU-27 countries in 2020 [ 1 ]. This makes it the most frequently occurring cancer, representing nearly 30% of all new diagnoses in women [ 1 ]. Recent …
verfasst von:
Luca Boldrini, Loredana Dinapoli, Edda Boccia, Morena Caliandro, Sarah Pia Colangione, Chiara Elia, Veronica Pollutri, Gaia Sartori, Fabiana Gregucci, Elisa Marconi, Stefania Manfrida, Valeria Masiello, Daniela Pia Rosaria Chieffo, Fabio Marazzi, Alba Fiorentino, Maria Antonietta Gambacorta
